OCTTC

List of New and Ongoing Clinical Trials and Research

PRINCIPAL INVESTIGATOR STUDY TITLE
CORNEA
Jose De la Cruz, MD Femtosecond Laser Assisted Cataract Surgery
 Sandeep Jain, MD A Phase I/II Open-Label, Single-Center, Tolerability And Preliminary Efficacy Study Of Recombinant Human Deoxyribonuclease (rhDNase) Eye Drops In Patients With Dry Eye Disease
 Sandeep Jain, MD A Phase I/II Randomized Placebo-Controlled, Double-Blind, Single-Center, Tolerability And Preliminary Efficacy Clinical Trial Of Recombinant Human Deoxyribonuclease (rhDNase) Eye Drops in Patients With ocular Graft-vs.-Host Disease
 Sandeep Jain, MD A Phase I/II Open-Label, Single-Center, Tolerability And Preliminary Efficacy Study of use of Brimonidine  Eye Drops for Treatment of ocular Graft-vs.-Host Disease (oGVHD)
 Sandeep Jain, MD Dry Eye Assessment and Management (DREAM) Study
 Sandeep Jain, MD A Prospective Study to Identify Bio-Markers that Predict Onset and Progression of ocular Graft-vs.-Host Disease in Patients who receive Allogeneic hematopoietic Stem Cell Transplant
 Sandeep Jain, MD Presence of Neutrophil Extracellular Traps (NETS) in Dry Eye Disease
Elmler Tu, MD Effect of Corneal Preservation Time on Long-Term Graft Success (CPTS)
Elmer Tu, MD Microbiologic Clearance Time for Acanthamoeba Keratitis
GLAUCOMA
Thasarat Vajaranant, MD The Efficacy and Safety of Bimatoprost SR in Patients With Open-angle Glaucoma or Ocular Hypertension
NEURO-OPHTHALMOLOGY
Heather Moss, MD, PhD
Peter MacIntosh, MD
A Phase 2/3, randomized double-masked, sham-controlled trial of QPI-1007 delivered by single or multi-dose intravitreal injection(s) to subjects with acute nonarteritic anterior ischemic optic neuropathy (NAION)
Heather Moss, MD, PhD A Phase 2/3 Research Study for the Treatment of Non-Arteritic Anterior
PEDIATRIC OPHTHALMOLOGY
Nathalie Azar, MD Pediatric Cataract Surgery Outcomes Registry (C02)
RETINA
Paul Chan, MD, MSc, FACS
A Phase 2b, Multicenter, Double-masked, Randomized Study Evaluating the Safety and Clinical Response of Subretinal Administration of CNTO 2476 in Subjects with Visual Acuity Impairment Associated with Geographic Atrophy Secondary to Age Related Macular Degeneration
Felix Chau, MD A randomized, controlled study evaluating the efficacy and safety of RAnibizumab compared with laser therapy for the treatment of INfants BOrn prematurely With retinopathy of prematurity
Jennifer Lim, MD Study of Comparative Treatments for Retinal Vein Occlusion 2 (SCORE2): A Multicenter, Prospective, Randomized Non-Inferiority Trial of Eyes with Macular Edema Secondary to Central Retinal Vein Occlusion, Comparing Intravitreal Bevacizumab every 4 Weeks with Intravitreal Aflibercept Every 4 Weeks Versus Intravitreal Aflibercept Every 4 Weeks
Jennifer Lim, MD Comparing effectiveness of intravitreal Aflibercept, Avastin and Eylea for Diabetic Macular Edema
Jennifer Lim, MD Argus II device implant for Retinitis Pigmentosa
Jennifer Lim, MD Genes in Diabetic Retinopathy Project
Jennifer Lim, MD Treatment for central-involved macular edema in eyes with very good vision
Jennifer Lim, MD Observational study for Peripheral Diabetic Retinopathy lesions on ultrawide-field imaging in non-proliferative diabetic retinopathy
Jennifer Lim, MD A 2-year randomized, double-masked, multicenter three-arm study comparing the efficacy and safety of RTH258 versus Aflibercept in subjects with neovascular age-related macular degeneration
Jennifer Lim, MD Observational safety of IOP signals in patients treated with ILUVIEN® (Fluocinolone Acetonide Intravitreal Implant)
Jennifer Lim, MD A Phase 3, Double-Masked, Randomized Study of the Efficacy and Safety of Intravitreal Aflibercept Injection in Patients with Moderately Severe to Severe Non-Proliferative Diabetic Retinopathy
Jennifer Lim, MD A Randomized, Double-Masked, Active-Controlled Phase 2 Study Of The Efficacy, Safety, And Tolerability Of Repeated Doses Of Intravitreal Regn910-3 In Patients With Neovascular Age-Related Macular Degeneration
Jennifer Lim, MD A Randomized, Double-Masked, Active-Controlled Phase 2 Study Of The Efficacy, Safety, And Tolerability Of Repeated Doses Of Intravitreal REGN910-3 In Patients With Diabetic Macular Edema
Jennifer Lim, MD A Multiple-Center, Multiple-Dose, Randomized, Active Comparator-Controlled, Double-Masked, Parallel Group, 28-Week Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO6867461 Administered Intravitreally in Patients with Diabetic Macular Edema
Jennifer Lim, MD Intravitreous Anti-VEGF Treatment for Prevention of Vision Threatening Diabetic Retinopathy in Eyes at High Risk
Jennifer Lim, MD Optical Coherence Tomographical Retinal Thickness Analysis of Sickle Cell Patients
Jennifer Lim, MD An Experimental Approach to Maculopathy
J. Jason McAnany, PhD Mechanisms Limiting Visual Performance in Retinal Degenerations
Mahnaz Shahidi, PhD Ocular Biomarkers of Microvascular Neural and Metabolic Function in Diabetes
UVEITIS
Ann-Marie Lobo, MD A Phase 3, Randomized,  Masked, Controlled Clinical Trial to Study the Safety and Efficacy of Triamcinolone Acetonide  Injectable Suspension  (CLS­ TA) for the Treatment of Subjects with Macular Edema associated with Non-Infectious Uveitis
Ann-Marie Lobo, MD A comparison of a fundus imaging system with ultra wide-field imaging and clinical exam for the detection of eye disease